InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GABRA5

Summary

InnateDB Gene

IDBG-628558.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRA5

Gene Name

Gamma-aminobutyric acid receptor subunit alpha-5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003392

Encoded Proteins

IDBP-679926

Gamma-aminobutyric acid receptor subunit alpha-5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186297:
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:4407154-4499274

Strand

Forward strand

Band

Transcripts

ENSBTAT00000004397

ENSBTAP00000004397

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005216	ion channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0001662	behavioral fear response
GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007605	sensory perception of sound
GO:0008306	associative learning
GO:0034220	ion transmembrane transport
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0048666	neuron development
GO:0060119	inner ear receptor cell development
GO:0060384	innervation
GO:0090102	cochlea development
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0034707	chloride channel complex
GO:0044297	cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane