Version 5.4
Homo sapiens Gene: NDUFB2
Summary
InnateDB Gene IDBG-44283.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDUFB2
Gene Name NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
Synonyms AGGG; CI-AGGG
Species Homo sapiens
Ensembl Gene ENSG00000090266
Encoded Proteins
IDBP-44287
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-476735
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-475661
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-482925
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-481413
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-481428
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-476961
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-478015
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-478263
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-484979
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-478539
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
IDBP-477462
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:140690777-140722790
Strand Forward strand
Band q34
Transcripts
ENST00000247866 ENSP00000247866
ENST00000482954 ENSP00000419392
ENST00000476279 ENSP00000419087
ENST00000461457 ENSP00000420062
ENST00000465506 ENSP00000419357
ENST00000464564
ENST00000476181 ENSP00000418347
ENST00000464566 ENSP00000419479
ENST00000460088 ENSP00000418953
ENST00000472695 ENSP00000418573
ENST00000476470 ENSP00000420377
ENST00000471136 ENSP00000419983
ENST00000462847
ENST00000475276 ENSP00000418981
ENST00000479181
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002416
View Gene Order
ENSBTAG00000021759
Not yet available
Pathways
NETPATH
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa00190
Oxidative phosphorylation pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt O95178
TrEMBL A4D1T5 C9IZZ2 H7C5B8
UniProt Splice Variant
Entrez Gene 4708
UniGene
RefSeq NM_004546
HUGO HGNC:7697
OMIM 603838
CCDS CCDS5862
HPRD 11953
IMGT
EMBL AC006344 AF050639 AF067166 BC001168 CH236950 CH471070 CR542121
GenPept AAD05428 AAD32450 CAG46918 EAL24024 EAW83958 EAW83959 EAW83961 EAW83962
RNA Seq Atlas 4708

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca