InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TMSB4X

Summary

InnateDB Gene

IDBG-44380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMSB4X

Gene Name

thymosin beta 4, X-linked

Synonyms

FX; PTMB4; TB4X; TMSB4

Species

Homo sapiens

Ensembl Gene

ENSG00000205542

Encoded Proteins

IDBP-44384

thymosin beta 4, X-linked

IDBP-44386

thymosin beta 4, X-linked

IDBP-44388

thymosin beta 4, X-linked

IDBP-362063

thymosin beta 4, X-linked

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:12975108-12977227

Strand

Forward strand

Band

p22.2

Transcripts

ENST00000380636	ENSP00000370010
ENST00000380635	ENSP00000370009
ENST00000380633	ENSP00000370007
ENST00000451311	ENSP00000414376

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	28 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002576	platelet degranulation
GO:0007010	cytoskeleton organization
GO:0007596	blood coagulation
GO:0030036	actin cytoskeleton organization
GO:0030168	platelet activation
GO:0042989	sequestering of actin monomers

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0031093	platelet alpha granule lumen

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000049775

View Gene Order

ENSBTAG00000038488

Not yet available

Pathways

NETPATH

REACTOME

REACT_318

Platelet degranulation pathway

REACT_1280

Response to elevated platelet cytosolic Ca2+ pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_604

Hemostasis pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

INOH

PID NCI

Cross-References

SwissProt

P62328

TrEMBL

A2VCK8 Q0P5N8 Q0P5P4 Q0P5Q0 Q0P5T0 Q0P5U7

UniProt Splice Variant

Entrez Gene

7114

UniGene

Hs.743694

RefSeq

NM_021109

HUGO

HGNC:11881

OMIM

300159

CCDS

CCDS35202

HPRD

02153

IMGT

EMBL

AJ295158 AK311747 BC001631 BC016732 BC022857 BC061586 BC062436 BC064954 BC070248 BC083509 BC092437 BC101790 BC101792 BC104464 BC104465 BC104666 BC128102 BC128103 BC139925 BC141975 BC141976 BC151215 BT007090 CH471074 M17733 X02493

GenPept

AAA36745 AAH01631 AAH16732 AAH22857 AAH61586 AAH62436 AAH64954 AAH70248 AAH83509 AAH92437 AAI01791 AAI01793 AAI04465 AAI04466 AAI04667 AAI28103 AAI28104 AAI39926 AAI41976 AAI41977 AAI51216 AAP35753 BAG34690 CAA26323 CAC43317 EAW98810 EAW98811 EAW98812 EAW98814

RNA Seq Atlas

7114