Version 5.4
Homo sapiens Gene: LARP4B
Summary
InnateDB Gene IDBG-44458.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LARP4B
Gene Name La ribonucleoprotein domain family, member 4B
Synonyms KIAA0217; LARP5
Species Homo sapiens
Ensembl Gene ENSG00000107929
Encoded Proteins
IDBP-44460
La ribonucleoprotein domain family, member 4B
IDBP-292545
La ribonucleoprotein domain family, member 4B
IDBP-361969
La ribonucleoprotein domain family, member 4B
IDBP-361975
La ribonucleoprotein domain family, member 4B
IDBP-361978
La ribonucleoprotein domain family, member 4B
IDBP-810107
La ribonucleoprotein domain family, member 4B
IDBP-810079
La ribonucleoprotein domain family, member 4B
IDBP-810111
La ribonucleoprotein domain family, member 4B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:806914-931705
Strand Reverse strand
Band p15.3
Transcripts
ENST00000316157 ENSP00000326128
ENST00000406525 ENSP00000385229
ENST00000448368 ENSP00000394545
ENST00000440895 ENSP00000403018
ENST00000412411 ENSP00000390556
ENST00000469487
ENST00000476529 ENSP00000476786
ENST00000481118
ENST00000614908 ENSP00000483973
ENST00000609318
ENST00000608970
ENST00000612396 ENSP00000482767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0045727 positive regulation of translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0042788 polysomal ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033499
View Gene Order
ENSBTAG00000013899
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.713649 Hs.721442
RefSeq NM_015155 XM_005252433
HUGO
OMIM
CCDS CCDS31131
HPRD 13787
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca