Version 5.4
Homo sapiens Protein: LARP4B
Summary
InnateDB Protein IDBP-44460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LARP4B
Protein Name La ribonucleoprotein domain family, member 4B
Synonyms KIAA0217; LARP5;
Species Homo sapiens
Ensembl Protein ENSP00000326128
InnateDB Gene IDBG-44458 (LARP4B)
Protein Structure
UniProt Annotation
Function Stimulates mRNA translation. {ECO:0000269PubMed:20573744}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:20573744}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs in response to arsenite treatment.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0045727 positive regulation of translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0042788 polysomal ribosome
Protein Structure and Domains
PDB ID
InterPro IPR006630 RNA-binding protein Lupus La
PFAM PF05383
PRINTS
PIRSF
SMART SM00715
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92615
PhosphoSite PhosphoSite-Q92615
TrEMBL X6RCG6
UniProt Splice Variant
Entrez Gene 23185
UniGene Hs.721442
RefSeq
HUGO HGNC:28987
OMIM
CCDS CCDS31131
HPRD 13787
IMGT
EMBL AK292946 AL157709 AL359878 BC131630 BC152443 CH471072 CR749653 D86971
GenPept AAI31631 AAI52444 BAA13207 BAF85635 CAH18446 CAI13661 CAI13662 CAI13663 CAI39596 EAW86530

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca