Version 5.4
Homo sapiens Gene: TAS2R4
Summary
InnateDB Gene IDBG-44579.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAS2R4
Gene Name taste receptor, type 2, member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127364
Encoded Proteins
IDBP-44581
taste receptor, type 2, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:141778442-141780819
Strand Forward strand
Band q34
Transcripts
ENST00000247881 ENSP00000247881
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008527 taste receptor activity
GO:0033038 bitter taste receptor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007585 respiratory gaseous exchange
GO:0050909 sensory perception of taste
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0060170 ciliary membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037140
View Gene Order
ENSBTAG00000018440
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_18319
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04742
Taste transduction pathway
INOH
PID NCI
Cross-References
SwissProt Q9NYW5
TrEMBL Q50KX5 Q50KX7
UniProt Splice Variant
Entrez Gene 50832
UniGene
RefSeq NM_016944
HUGO HGNC:14911
OMIM 604869
CCDS CCDS5868
HPRD
IMGT
EMBL AB199016 AB199017 AB199018 AC004979 AF227131 AY724958
GenPept AAF43904 AAS02039 AAU21154 BAD97921 BAD97922 BAD97923
RNA Seq Atlas 50832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca