InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAS2R4

Summary

InnateDB Protein

IDBP-44581.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAS2R4

Protein Name

taste receptor, type 2, member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000247881

InnateDB Gene

IDBG-44579 (TAS2R4)

Protein Structure

UniProt Annotation

Function

Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. {ECO:0000269PubMed:19628819}.

Subcellular Localization

Membrane {ECO:0000269PubMed:19628819}; Multi-pass membrane protein {ECO:0000269PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.

Disease Associations

Tissue Specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed on airway ciliated epithelium. {ECO:0000269PubMed:19628819}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008527	taste receptor activity
GO:0033038	bitter taste receptor activity

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007585	respiratory gaseous exchange
GO:0050909	sensory perception of taste