Version 5.4
Homo sapiens Gene: CDKL3
Summary
InnateDB Gene IDBG-44793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDKL3
Gene Name cyclin-dependent kinase-like 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006837
Encoded Proteins
IDBP-44795
cyclin-dependent kinase-like 3
IDBP-478330
cyclin-dependent kinase-like 3
IDBP-479971
cyclin-dependent kinase-like 3
IDBP-480289
cyclin-dependent kinase-like 3
IDBP-475177
cyclin-dependent kinase-like 3
IDBP-474536
cyclin-dependent kinase-like 3
IDBP-481523
cyclin-dependent kinase-like 3
IDBP-478911
cyclin-dependent kinase-like 3
IDBP-476615
cyclin-dependent kinase-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134286350-134371047
Strand Reverse strand
Band q31.1
Transcripts
ENST00000265334 ENSP00000265334
ENST00000520515
ENST00000518409
ENST00000520693 ENSP00000430777
ENST00000519312 ENSP00000427738
ENST00000518990 ENSP00000427836
ENST00000523054 ENSP00000428500
ENST00000521118 ENSP00000428689
ENST00000520592 ENSP00000428498
ENST00000523832 ENSP00000430496
ENST00000521755 ENSP00000427964
ENST00000522501
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 9 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0030517 negative regulation of axon extension
GO:0050775 positive regulation of dendrite morphogenesis
GO:0051726 regulation of cell cycle
GO:0097484 dendrite extension
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020389
View Gene Order
ENSBTAG00000010979
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.719926
RefSeq NM_001113575 NM_001300853 NM_016508 XM_005272004
HUGO
OMIM
CCDS CCDS47264 CCDS47265 CCDS75303
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca