InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SAR1B

Summary

InnateDB Gene

IDBG-44984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAR1B

Gene Name

SAR1 homolog B (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000152700

Encoded Proteins

IDBP-295715

SAR1 homolog B (S. cerevisiae)

IDBP-377010

SAR1 homolog B (S. cerevisiae)

IDBP-484250

SAR1 homolog B (S. cerevisiae)

IDBP-475648

SAR1 homolog B (S. cerevisiae)

IDBP-474914

SAR1 homolog B (S. cerevisiae)

IDBP-477787

SAR1 homolog B (S. cerevisiae)

IDBP-473479

SAR1 homolog B (S. cerevisiae)

IDBP-482389

SAR1 homolog B (S. cerevisiae)

IDBP-484684

SAR1 homolog B (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:134601144-134649271

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000402673	ENSP00000385432
ENST00000439578	ENSP00000404997
ENST00000507419	ENSP00000425339
ENST00000508363
ENST00000502539	ENSP00000426335
ENST00000509937	ENSP00000424673
ENST00000509730	ENSP00000423197
ENST00000503318	ENSP00000425367
ENST00000505758	ENSP00000425466
ENST00000502286	ENSP00000423005
ENST00000504242

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0016192	vesicle-mediated transport
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0048208	COPII vesicle coating
GO:0061024	membrane organization

Cellular Component

GO:0005622	intracellular
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0032580	Golgi cisterna membrane