Version 5.4
| Homo sapiens Gene: WIF1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-45232.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | WIF1 | ||||||||||||||||||
| Gene Name | WNT inhibitory factor 1 | ||||||||||||||||||
| Synonyms | WIF-1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000156076 | ||||||||||||||||||
| Encoded Proteins |
WNT inhibitory factor 1
WNT inhibitory factor 1
WNT inhibitory factor 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 12:65050626-65121566 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q14.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH |
Wnt pathway
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| REACTOME |
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
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| KEGG |
Wnt signaling pathway pathway
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| INOH |
Wnt signaling pathway pathway
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| PID NCI |
Presenilin action in Notch and Wnt signaling
Wnt signaling network
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| Cross-References | |||||||||||||||||||
| SwissProt | Q9Y5W5 | ||||||||||||||||||
| TrEMBL | B4DX53 F5H8A3 H0YFK7 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 11197 | ||||||||||||||||||
| UniGene | Hs.284122 | ||||||||||||||||||
| RefSeq | NM_007191 | ||||||||||||||||||
| HUGO | HGNC:18081 | ||||||||||||||||||
| OMIM | 605186 | ||||||||||||||||||
| CCDS | CCDS8971 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC026124 AC135895 AF122922 AK301818 AY358344 BC018037 | ||||||||||||||||||
| GenPept | AAD25402 AAH18037 AAQ88710 BAG63265 | ||||||||||||||||||
| RNA Seq Atlas | 11197 | ||||||||||||||||||