Version 5.4
Homo sapiens Gene: SPTSSA
Summary
InnateDB Gene IDBG-4525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPTSSA
Gene Name serine palmitoyltransferase, small subunit A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165389
Encoded Proteins
IDBP-4527
serine palmitoyltransferase, small subunit A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:34432789-34462356
Strand Reverse strand
Band q13.1
Transcripts
ENST00000298130 ENSP00000298130
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004758 serine C-palmitoyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0030148 sphingolipid biosynthetic process
Cellular Component
GO:0016021 integral component of membrane
GO:0017059 serine C-palmitoyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044408
View Gene Order
ENSBTAG00000013981
Not yet available
Cross-References
SwissProt Q969W0
TrEMBL
UniProt Splice Variant
Entrez Gene 171546
UniGene Hs.740577
RefSeq NM_138288
HUGO HGNC:20361
OMIM 613540
CCDS CCDS9647
HPRD
IMGT
EMBL AK315409 BC016805 BC016808 BC021701 BC068480 CH471078
GenPept AAH16805 AAH16808 AAH21701 AAH68480 BAG37801 EAW65923 EAW65924
RNA Seq Atlas 171546

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca