Version 5.4
Homo sapiens Protein: SPTSSA
Summary
InnateDB Protein IDBP-4527.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPTSSA
Protein Name serine palmitoyltransferase, small subunit A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000298130
InnateDB Gene IDBG-4525 (SPTSSA)
Protein Structure
UniProt Annotation
Function Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2- SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16- CoA as substrates, with a slight preference for C14-CoA. {ECO:0000269PubMed:19416851}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004758 serine C-palmitoyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0030148 sphingolipid biosynthetic process
Cellular Component
GO:0016021 integral component of membrane
GO:0017059 serine C-palmitoyltransferase complex
Protein Structure and Domains
PDB ID
InterPro IPR024512 Small subunit of serine palmitoyltransferase-like
PFAM PF11779
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969W0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 171546
UniGene Hs.740577
RefSeq NP_612145
HUGO HGNC:20361
OMIM 613540
CCDS CCDS9647
HPRD 16610
IMGT
EMBL AK315409 BC016805 BC016808 BC021701 BC068480 CH471078
GenPept AAH16805 AAH16808 AAH21701 AAH68480 BAG37801 EAW65923 EAW65924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca