Version 5.4
Homo sapiens Gene: MYL12B
Summary
InnateDB Gene IDBG-455.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL12B
Gene Name myosin, light chain 12B, regulatory
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118680
Encoded Proteins
IDBP-457
myosin, light chain 12B, regulatory
IDBP-228859
myosin, light chain 12B, regulatory
IDBP-726705
IDBP-727352
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:3261909-3278284
Strand Forward strand
Band p11.31
Transcripts
ENST00000237500 ENSP00000237500
ENST00000400175 ENSP00000383037
ENST00000584539 ENSP00000464464
ENST00000581193 ENSP00000463559
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006936 muscle contraction
GO:0007411 axon guidance
GO:0008360 regulation of cell shape
Cellular Component
GO:0001725 stress fiber
GO:0005829 cytosol
GO:0016460 myosin II complex
GO:0030018 Z disc
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000034868
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_20558
Smooth Muscle Contraction pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04510
Focal adhesion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.594402
RefSeq NM_001144944 NM_001144945 NM_033546
HUGO
OMIM
CCDS CCDS11831
HPRD 10095
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca