Version 5.4
Homo sapiens Gene: LECT2
Summary
InnateDB Gene IDBG-45781.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LECT2
Gene Name leukocyte cell-derived chemotaxin 2
Synonyms chm-II; chm2
Species Homo sapiens
Ensembl Gene ENSG00000145826
Encoded Proteins
IDBP-45783
leukocyte cell-derived chemotaxin 2
IDBP-478742
leukocyte cell-derived chemotaxin 2
IDBP-473939
leukocyte cell-derived chemotaxin 2
IDBP-477779
leukocyte cell-derived chemotaxin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:135922279-135955034
Strand Reverse strand
Band q31.1
Transcripts
ENST00000274507 ENSP00000274507
ENST00000522943 ENSP00000429618
ENST00000471827
ENST00000512872 ENSP00000427012
ENST00000514447 ENSP00000421123
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0042802 identical protein binding
Biological Process
GO:0001501 skeletal system development
GO:0006935 chemotaxis
GO:0030178 negative regulation of Wnt signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021539
View Gene Order
ENSBTAG00000001247
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.512580
RefSeq NM_002302
HUGO
OMIM
CCDS CCDS4190
HPRD 04196
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca