InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LECT2

Summary

InnateDB Protein

IDBP-45783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LECT2

Protein Name

leukocyte cell-derived chemotaxin 2

Synonyms

chm-II; chm2;

Species

Homo sapiens

Ensembl Protein

ENSP00000274507

InnateDB Gene

IDBG-45781 (LECT2)

Protein Structure

UniProt Annotation

Function

Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:8877413}. Secreted {ECO:0000269PubMed:8877413}.

Disease Associations

Tissue Specificity

Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0042802	identical protein binding

Biological Process

GO:0001501	skeletal system development
GO:0006935	chemotaxis
GO:0030178	negative regulation of Wnt signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR016047 Peptidase M23
IPR017381 Leukocyte cell-derived chemotaxin 2, chordata

PFAM

PF01551

PRINTS

PIRSF

PIRSF038085

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O14960

PhosphoSite

PhosphoSite-

TrEMBL

D6RD58

UniProt Splice Variant

Entrez Gene

3950

UniGene

Hs.512580

RefSeq

NP_002293

HUGO

HGNC:6550

OMIM

602882

CCDS

CCDS4190

HPRD

04196

IMGT

EMBL

AB007546 AC002428 AC004763 AK314092 BC093670 BC101579 D63521

GenPept

AAB66905 AAC17734 AAH93670 AAI01580 BAA23609 BAA25669 BAG36787