InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PROS1

Summary

InnateDB Gene

IDBG-46049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROS1

Gene Name

protein S (alpha)

Synonyms

PROS; PS21; PS22; PS23; PS24; PS25; PSA; THPH5; THPH6

Species

Homo sapiens

Ensembl Gene

ENSG00000184500

Encoded Proteins

IDBP-46051

protein S (alpha)

IDBP-242005

protein S (alpha)

IDBP-295380

protein S (alpha)

IDBP-482468

protein S (alpha)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22043818

PROS1 works with GAS6 to synergistically suppress the basal and TLR-triggered production of inflammatory cytokines in macrophages. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22043818

[Mus musculus] Pros1 works with Gas6 to synergistically suppress the basal and TLR-triggered production of inflammatory cytokines in macrophages.

Entrez Gene

Summary

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:93873033-93974066

Strand

Reverse strand

Band

q11.1

Transcripts

ENST00000348974	ENSP00000330021
ENST00000394236	ENSP00000377783
ENST00000407433	ENSP00000385794
ENST00000472684	ENSP00000419616
ENST00000488658

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0002576	platelet degranulation
GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0010951	negative regulation of endopeptidase activity
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0030168	platelet activation
GO:0030449	regulation of complement activation
GO:0042730	fibrinolysis
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0050900	leukocyte migration

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005789	endoplasmic reticulum membrane
GO:0005796	Golgi lumen
GO:0031093	platelet alpha granule lumen
GO:0072562	blood microparticle