Version 5.4
| Mus musculus Gene: Pros1 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-170363.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Pros1 | ||||||||||||||||||||||
| Gene Name | protein S (alpha) | ||||||||||||||||||||||
| Synonyms | AW214361 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000022912 | ||||||||||||||||||||||
| Encoded Proteins |
protein S (alpha)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
Pros1 works with Gas6 to synergistically suppress the basal and TLR-triggered production of inflammatory cytokines in macrophages.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] PROS1 works with GAS6 to synergistically suppress the basal and TLR-triggered production of inflammatory cytokines in macrophages. (Demonstrated in mice)
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184500:
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 16:62854307-62929346 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | C1.3 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Platelet degranulation pathway
Hemostasis pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Cell surface interactions at the vascular wall pathway
Platelet activation, signaling and aggregation pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Gamma-carboxylation of protein precursors pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Response to elevated platelet cytosolic Ca2+ pathway
Common Pathway pathway
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| KEGG |
Complement and coagulation cascades pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Regulation of Complement cascade pathway
Cell surface interactions at the vascular wall pathway
Common Pathway pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Gamma-carboxylation of protein precursors pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Post-translational protein modification pathway
Innate Immune System pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Platelet activation, signaling and aggregation pathway
Metabolism of proteins pathway
Immune System pathway
Complement cascade pathway
Hemostasis pathway
Platelet degranulation pathway
Gamma-carboxylation of protein precursors pathway
Cell surface interactions at the vascular wall pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Common Pathway pathway
Hemostasis pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Regulation of Complement cascade pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Complement cascade pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Innate Immune System pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
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| KEGG |
Complement and coagulation cascades pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | Q08761 | ||||||||||||||||||||||
| TrEMBL | Q3TR66 Q3V0M0 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 19128 | ||||||||||||||||||||||
| UniGene | Mm.127156 Mm.401335 | ||||||||||||||||||||||
| RefSeq | NM_011173 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS28263 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:1095733 | ||||||||||||||||||||||
| MGI Symbol | Pros1 | ||||||||||||||||||||||
| EMBL | AK133044 AK145501 AK163032 BC128316 CH466521 L27439 Z25469 | ||||||||||||||||||||||
| GenPept | AAA40006 AAI28317 BAE21484 BAE26474 BAE37164 CAA80961 EDK98237 | ||||||||||||||||||||||
| RNA Seq Atlas | 19128 | ||||||||||||||||||||||