Version 5.4
Homo sapiens Gene: GPR183
Summary
InnateDB Gene IDBG-46148.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR183
Gene Name G protein-coupled receptor 183
Synonyms EBI2
Species Homo sapiens
Ensembl Gene ENSG00000169508
Encoded Proteins
IDBP-46150
G protein-coupled receptor 183
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:99294530-99307405
Strand Reverse strand
Band q32.3
Transcripts
ENST00000376414 ENSP00000365596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008142 oxysterol binding
Biological Process
GO:0002313 mature B cell differentiation involved in immune response
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0030890 positive regulation of B cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051212
View Gene Order
ENSBTAG00000032084
Not yet available
Cross-References
SwissProt P32249
TrEMBL A0A024RDX2
UniProt Splice Variant
Entrez Gene 1880
UniGene Hs.658897 Hs.679062 Hs.784
RefSeq NM_004951
HUGO HGNC:3128
OMIM 605741
CCDS CCDS9492
HPRD
IMGT
EMBL AK223390 AK292091 AK313443 AL160155 BC020752 CH471085 L08177
GenPept AAA35924 AAH20752 BAD97110 BAF84780 BAG36232 CAI14308 EAX09018 EAX09019
RNA Seq Atlas 1880

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca