InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR183

Summary

InnateDB Protein

IDBP-46150.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR183

Protein Name

G protein-coupled receptor 183

Synonyms

EBI2;

Species

Homo sapiens

Ensembl Protein

ENSP00000365596

InnateDB Gene

IDBG-46148 (GPR183)

Protein Structure

UniProt Annotation

Function

Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7- alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2). {ECO:0000250, ECO:0000269PubMed:16540462, ECO:0000269PubMed:21673108}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16540462, ECO:0000269PubMed:21673108}; Multi-pass membrane protein {ECO:0000269PubMed:16540462, ECO:0000269PubMed:21673108}.

Disease Associations

Tissue Specificity

Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain. {ECO:0000269PubMed:16540462, ECO:0000269PubMed:8383238}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008142	oxysterol binding

Biological Process

GO:0002313	mature B cell differentiation involved in immune response
GO:0006955	immune response
GO:0006959	humoral immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0030890	positive regulation of B cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32249