Homo sapiens Gene: APLNR | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-46271.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | APLNR | ||||||||||
Gene Name | apelin receptor | ||||||||||
Synonyms | AGTRL1; APJ; APJR; HG11 | ||||||||||
Species | Homo sapiens | ||||||||||
Ensembl Gene | ENSG00000134817 | ||||||||||
Encoded Proteins |
apelin receptor
apelin receptor
apelin receptor
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 11:57233577-57237314 | ||||||||||
Strand | Reverse strand | ||||||||||
Band | q12.1 | ||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||
NETPATH | |||||||||||
REACTOME |
G alpha (i) signalling events pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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KEGG |
Neuroactive ligand-receptor interaction pathway
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INOH | |||||||||||
PID NCI | |||||||||||
Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | |||||||||||
UniGene | |||||||||||
RefSeq | NM_005161 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | CCDS7950 | ||||||||||
HPRD | 02503 | ||||||||||
IMGT | |||||||||||
EMBL | |||||||||||
GenPept | |||||||||||
RNA Seq Atlas | |||||||||||