Version 5.4
| Homo sapiens Protein: APLNR | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-46273.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | APLNR | ||||||||
| Protein Name | apelin receptor | ||||||||
| Synonyms | AGTRL1; APJ; APJR; HG11; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000257254 | ||||||||
| InnateDB Gene | IDBG-46271 (APLNR) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. | ||||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000248
Angiotensin II receptor family IPR000276 G protein-coupled receptor, rhodopsin-like IPR003904 APJ receptor IPR007960 Mammalian taste receptor IPR017452 GPCR, rhodopsin-like, 7TM IPR019426 7TM GPCR, serpentine receptor class v (Srv) |
||||||||
| PFAM |
PF00001
PF05296 PF10323 |
||||||||
| PRINTS |
PR00241
PR00237 PR01416 |
||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P35414 | ||||||||
| PhosphoSite | PhosphoSite-P35414 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 187 | ||||||||
| UniGene | |||||||||
| RefSeq | |||||||||
| HUGO | HGNC:339 | ||||||||
| OMIM | 600052 | ||||||||
| CCDS | CCDS7950 | ||||||||
| HPRD | 02503 | ||||||||
| IMGT | |||||||||
| EMBL | BC032688 U03642 X89271 | ||||||||
| GenPept | AAA18954 AAH32688 CAA61546 | ||||||||