InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BMX

Summary

InnateDB Gene

IDBG-46340.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMX

Gene Name

BMX non-receptor tyrosine kinase

Synonyms

ETK; PSCTK2; PSCTK3

Species

Homo sapiens

Ensembl Gene

ENSG00000102010

Encoded Proteins

IDBP-46344

BMX non-receptor tyrosine kinase

IDBP-46346

BMX non-receptor tyrosine kinase

IDBP-46348

BMX non-receptor tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18025155

A tyrosine protein kinase that regulates TLR4 induced IL6 in macrophages independent of MAPK14 (p38-alpha) and NF-kappaB

Entrez Gene

Summary

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:15464246-15556529

Strand

Forward strand

Band

p22.2

Transcripts

ENST00000357607	ENSP00000350224
ENST00000348343	ENSP00000308774
ENST00000342014	ENSP00000340082
ENST00000463891
ENST00000489983

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006950	response to stress
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007498	mesoderm development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005829	cytosol
GO:0032587	ruffle membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031377

View Gene Order

ENSBTAG00000000377

Not yet available

Pathways

NETPATH

NetPath_18

IL6 pathway

REACTOME

REACT_107

Apoptotic cleavage of cellular proteins pathway

REACT_995

Apoptotic execution phase pathway

REACT_578

Apoptosis pathway

KEGG

INOH

PID NCI

fak_pathway

Signaling events mediated by focal adhesion kinase

angiopoietinreceptor_pathway

Angiopoietin receptor Tie2-mediated signaling

Cross-References

SwissProt

P51813

TrEMBL

UniProt Splice Variant

Entrez Gene

660

UniGene

Hs.495731

RefSeq

NM_001721 NM_203281 XM_006724510

HUGO

HGNC:1079

OMIM

300101

CCDS

CCDS14168

HPRD

IMGT

EMBL

AC097625 AF045459 BC016652 CH471074 U08341 X83107

GenPept

AAA17744 AAC08966 AAH16652 CAA58169 EAW98889

RNA Seq Atlas

660