InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bmx

Summary

InnateDB Gene

IDBG-184635.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmx

Gene Name

BMX non-receptor tyrosine kinase

Synonyms

Etk; Etk/Bmx; Tyro8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031377

Encoded Proteins

IDBP-256369

BMX non-receptor tyrosine kinase

IDBP-256371

BMX non-receptor tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18025155

[Homo sapiens] A tyrosine protein kinase that regulates TLR4 induced IL6 in macrophages independent of MAPK14 (p38-alpha) and NF-kappaB

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102010:
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:164192842-164258193

Strand

Reverse strand

Band

Transcripts

ENSMUST00000112265	ENSMUSP00000107884
ENSMUST00000112263	ENSMUSP00000107882

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0032587	ruffle membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000102010

View Gene Order

ENSBTAG00000000377

Not yet available

Pathways

NETPATH

REACTOME

REACT_258521

Apoptosis pathway

REACT_224460

Apoptotic cleavage of cellular proteins pathway

REACT_207035

Apoptotic execution phase pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_18

IL6 pathway

REACTOME

REACT_107

Apoptotic cleavage of cellular proteins pathway

REACT_995

Apoptotic execution phase pathway

REACT_578

Apoptosis pathway

KEGG

INOH

PID NCI

fak_pathway

Signaling events mediated by focal adhesion kinase

angiopoietinreceptor_pathway

Angiopoietin receptor Tie2-mediated signaling

Cross-References

SwissProt

P97504

TrEMBL

B1AUL5

UniProt Splice Variant

Entrez Gene

12169

UniGene

Mm.504

RefSeq

NM_009759

OMIM

CCDS

CCDS30519

HPRD

IMGT

MGI ID

MGI:1101778

MGI Symbol

Bmx

EMBL

AF012104 AK036707 AK040936 BC138104 BC138105 CH466571 U88091

GenPept

AAB47770 AAC53370 AAI38105 AAI38106 BAC29542 BAC30753 EDL40760

RNA Seq Atlas

12169