InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT8A

Summary

InnateDB Gene

IDBG-46500.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT8A

Gene Name

wingless-type MMTV integration site family, member 8A

Synonyms

WNT8D

Species

Homo sapiens

Ensembl Gene

ENSG00000061492

Encoded Proteins

IDBP-46502

wingless-type MMTV integration site family, member 8A

IDBP-232306

wingless-type MMTV integration site family, member 8A

IDBP-476435

wingless-type MMTV integration site family, member 8A

IDBP-484226

wingless-type MMTV integration site family, member 8A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. It encodes a protein which shows 81% amino acid identity to the mouse Wnt8A protein. [provided by RefSeq, Jul 2008]
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:138083892-138092365

Strand

Forward strand

Band

q31.2

Transcripts

ENST00000361560	ENSP00000354726
ENST00000398754	ENSP00000381739
ENST00000506684	ENSP00000426653
ENST00000504809	ENSP00000424809

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0048018	receptor agonist activity

Biological Process

GO:0000902	cell morphogenesis
GO:0003002	regionalization
GO:0007275	multicellular organismal development
GO:0007492	endoderm development
GO:0009949	polarity specification of anterior/posterior axis
GO:0010085	polarity specification of proximal/distal axis
GO:0014034	neural crest cell fate commitment
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0032526	response to retinoic acid
GO:0032880	regulation of protein localization
GO:0044324	regulation of transcription involved in anterior/posterior axis specification
GO:0044335	canonical Wnt receptor signaling pathway involved in neural crest cell differentiation
GO:0048561	establishment of organ orientation
GO:0060021	palate development
GO:0060070	canonical Wnt signaling pathway
GO:0061317	canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment