InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WNT8A

Summary

InnateDB Protein

IDBP-232306.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT8A

Protein Name

wingless-type MMTV integration site family, member 8A

Synonyms

WNT8D;

Species

Homo sapiens

Ensembl Protein

ENSP00000381739

InnateDB Gene

IDBG-46500 (WNT8A)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0048018	receptor agonist activity

Biological Process

GO:0007275	multicellular organismal development
GO:0014034	neural crest cell fate commitment
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0032526	response to retinoic acid
GO:0044324	regulation of transcription involved in anterior/posterior axis specification
GO:0044335	canonical Wnt receptor signaling pathway involved in neural crest cell differentiation
GO:0060021	palate development
GO:0060070	canonical Wnt signaling pathway
GO:0061317	canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment