Version 5.4
Homo sapiens Gene: PRG2
Summary
InnateDB Gene IDBG-46552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRG2
Gene Name proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Synonyms BMPG; MBP; MBP1
Species Homo sapiens
Ensembl Gene ENSG00000186652
Encoded Proteins
IDBP-46554
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
IDBP-597608
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
IDBP-597587
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:57386794-57390657
Strand Reverse strand
Band q12.1
Transcripts
ENST00000311862 ENSP00000312134
ENST00000533605 ENSP00000433231
ENST00000525955 ENSP00000433016
ENST00000530105
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 7 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008201 heparin binding
GO:0030246 carbohydrate binding
Biological Process
GO:0002215 defense response to nematode
GO:0006955 immune response
GO:0032693 negative regulation of interleukin-10 production
GO:0032753 positive regulation of interleukin-4 production
GO:0042742 defense response to bacterium
Cellular Component
GO:0005576 extracellular region
GO:0030133 transport vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000027073
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa05310
Asthma pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001243245 NM_002728
HUGO
OMIM
CCDS CCDS58133 CCDS7955
HPRD 09283
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca