InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRG2

Summary

InnateDB Protein

IDBP-46554.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRG2

Protein Name

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

Synonyms

BMPG; MBP; MBP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000312134

InnateDB Gene

IDBG-46552 (PRG2)

Protein Structure

UniProt Annotation

Function

Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. {ECO:0000269PubMed:10913121}.

Subcellular Localization

Bone marrow proteoglycan: Secreted. Note=The proform is secreted.Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).

Disease Associations

Tissue Specificity

High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. {ECO:0000269PubMed:10491647, ECO:0000269PubMed:7526035}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	7 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008201	heparin binding
GO:0030246	carbohydrate binding

Biological Process

GO:0002215	defense response to nematode
GO:0006955	immune response
GO:0032693	negative regulation of interleukin-10 production
GO:0032753	positive regulation of interleukin-4 production
GO:0042742	defense response to bacterium