Version 5.4
Homo sapiens Gene: CAPNS1
Summary
InnateDB Gene IDBG-46584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPNS1
Gene Name calpain, small subunit 1
Synonyms 30K; CALPAIN4; CANP; CANPS; CAPN4; CDPS; CSS1
Species Homo sapiens
Ensembl Gene ENSG00000126247
Encoded Proteins
IDBP-46586
calpain, small subunit 1
IDBP-763553
IDBP-807541
calpain, small subunit 1
IDBP-760647
IDBP-766255
IDBP-807530
calpain, small subunit 1
IDBP-766259
IDBP-807537
calpain, small subunit 1
IDBP-764267
IDBP-765812
IDBP-761951
IDBP-761125
IDBP-807532
calpain, small subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:36139575-36150353
Strand Forward strand
Band q13.12
Transcripts
ENST00000246533 ENSP00000246533
ENST00000592483 ENSP00000468591
ENST00000586963 ENSP00000475804
ENST00000589162
ENST00000588815 ENSP00000464849
ENST00000588780 ENSP00000466113
ENST00000590049 ENSP00000474036
ENST00000587718 ENSP00000468041
ENST00000592354 ENSP00000475159
ENST00000591041 ENSP00000466386
ENST00000589146 ENSP00000466601
ENST00000586851 ENSP00000464903
ENST00000590874 ENSP00000465575
ENST00000590211 ENSP00000474280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
Experimentally validated
Total 64 [view]
Protein-Protein 63 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0008284 positive regulation of cell proliferation
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001794
View Gene Order
ENSBTAG00000014872
Not yet available
Pathways
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515371
RefSeq NM_001003962 NM_001749 XM_005259295 XM_005259296
HUGO
OMIM
CCDS CCDS12489
HPRD 00240
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca