Homo sapiens Gene: SLC25A4
Summary
InnateDB Gene IDBG-46664.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol SLC25A4
Gene Name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Synonyms AAC1; ANT; ANT1; PEO2; PEO3; T1;
Species Homo sapiens
Ensembl Gene ENSG00000151729
Encoded Proteins
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Protein Structure
Entrez Gene
Summary This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:186064395-186068434
Strand Forward strand
Band q35.1
Transcripts
ENST00000281456 ENSP00000281456
ENST00000515584
ENST00000491736
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005471 ATP:ADP antiporter activity
GO:0005515 protein binding
GO:0015207 adenine transmembrane transporter activity
GO:0019899 enzyme binding
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006091 generation of precursor metabolites and energy
GO:0006112 energy reserve metabolic process
GO:0006810 transport
GO:0008637 apoptotic mitochondrial changes
GO:0015853 adenine transport
GO:0015866 ADP transport
GO:0015867 ATP transport
GO:0016032 viral reproduction
GO:0019048 virus-host interaction
GO:0044281 small molecule metabolic process
GO:0050796 regulation of insulin secretion
GO:0051935 L-glutamate uptake involved in synaptic transmission
GO:0060547 negative regulation of necrotic cell death
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005887 integral to plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
Mitochondrial Protein Import pathway
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization pathway
KEGG
Huntington`s disease pathway
Parkinson`s disease pathway
Calcium signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P12235
TrEMBL
UniProt Splice Variant
Entrez Gene 291
UniGene Hs.246506
RefSeq NM_001151
HUGO 10990
OMIM 103220
CCDS CCDS34114
HPRD 00058
IMGT
EMBL BC008664 BC061589 BC063643 CH471056 HQ206346 HQ206347 HQ206348 HQ206349 HQ206350 HQ206351 HQ206352 HQ206353 HQ206354 HQ206355 HQ206356 HQ206357 HQ206358 HQ206359 HQ206360 HQ206361 HQ206362 HQ206363 HQ206364 HQ206365 HQ206366 HQ206367 HQ206368 HQ206369 HQ206370 HQ206371 HQ206372 HQ206373 HQ206374 HQ206375 HQ206376 HQ206377 HQ206378 HQ206379 HQ206380 HQ206381 HQ206382 HQ206383 HQ206384 HQ206385 J02966 J03593 J04982
GenPept AAA36751 AAA51736 AAA61223 AAH08664 AAH61589 AAH63643 ADP92294 ADP92295 ADP92296 ADP92297 ADP92298 ADP92299 ADP92300 ADP92301 ADP92302 ADP92303 ADP92304 ADP92305 ADP92306 ADP92307 ADP92308 ADP92309 ADP92310 ADP92311 ADP92312 ADP92313 ADP92314 ADP92315 ADP92316 ADP92317 ADP92318 ADP92319 ADP92320 ADP92321 ADP92322 ADP92323 ADP92324 ADP92325 ADP92326 ADP92327 ADP92328 ADP92329 ADP92330 ADP92331 ADP92332 ADP92333 EAX04655 EAX04656
ImmGen SLC25A4 (murine)
RNA Seq Atlas 291