InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CUL1

Summary

InnateDB Gene

IDBG-46918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUL1

Gene Name

cullin 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000055130

Encoded Proteins

IDBP-46920

cullin 1

IDBP-293919

cullin 1

IDBP-807321

cullin 1

IDBP-807326

cullin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:148697914-148801036

Strand

Forward strand

Band

q36.1

Transcripts

ENST00000325222	ENSP00000326804
ENST00000409469	ENSP00000387160
ENST00000602748	ENSP00000473318
ENST00000617797	ENSP00000482123

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 775 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	775 [view]
Protein-Protein	774 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006513	protein monoubiquitination
GO:0006915	apoptotic process
GO:0007050	cell cycle arrest
GO:0007219	Notch signaling pathway
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex
GO:0031461	cullin-RING ubiquitin ligase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029686

View Gene Order

ENSBTAG00000008736

Not yet available

Pathways

NETPATH

NetPath_3

Notch pathway

NetPath_7

TGF_beta_Receptor pathway

NetPath_9

TNFalpha pathway

REACTOME

REACT_6821

SCF-beta-TrCP mediated degradation of Emi1 pathway

REACT_6837

Regulation of APC/C activators between G1/S and early anaphase pathway

REACT_9003

SCF(Skp2)-mediated degradation of p27/p21 pathway

REACT_9029

Cyclin A:Cdk2-associated events at S phase entry pathway

REACT_1574

Cyclin E associated events during G1/S transition pathway

REACT_821

Cyclin D associated events in G1 pathway

REACT_160315

Regulation of PLK1 Activity at G2/M Transition pathway

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_22442

Interleukin-1 signaling pathway

REACT_115697

Prolactin receptor signaling pathway

REACT_118656

Activation of NF-kappaB in B cells pathway

REACT_116022

Nuclear signaling by ERBB4 pathway

REACT_115596

Signaling by ERBB4 pathway

REACT_118780

NOTCH1 Intracellular Domain Regulates Transcription pathway

REACT_11063

Degradation of beta-catenin by the destruction complex pathway

REACT_24941

Circadian Clock pathway

REACT_160243

Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway

REACT_160305

Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway

REACT_160254

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway

REACT_228216

truncated APC mutants destabilize the destruction complex pathway

REACT_1590

G1 Phase pathway

REACT_228098

AXIN mutants destabilize the destruction complex, activating WNT signaling pathway

REACT_228143

APC truncation mutants are not K63 polyubiquitinated pathway

REACT_228134

Signaling by Hedgehog pathway

REACT_228243

AMER1 mutants destabilize the destruction complex pathway

REACT_160082

Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway

REACT_228331

Signaling by WNT in cancer pathway

REACT_6828

APC/C-mediated degradation of cell cycle proteins pathway

REACT_228285

AXIN missense mutants destabilize the destruction complex pathway

REACT_21279

Regulation of mitotic cell cycle pathway

REACT_11045

Signaling by Wnt pathway

REACT_21267

Mitotic G1-G1/S phases pathway

REACT_160214

Signaling by NOTCH1 in Cancer pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_899

S Phase pathway

REACT_228196

APC truncation mutants have impaired AXIN binding pathway

REACT_206597

Degradation of GLI2 by the proteasome pathway

REACT_231645

GLI3 is processed to GLI3R by the proteasome pathway

REACT_228261

T41 mutants of beta-catenin aren't phosphorylated pathway

REACT_267605

Degradation of GLI1 by the proteasome pathway

REACT_160099

FBXW7 Mutants and NOTCH1 in Cancer pathway

REACT_1783

G1/S Transition pathway

REACT_111102

Signal Transduction pathway

REACT_267634

Hedgehog 'off' state pathway

REACT_228314

misspliced GSK3beta mutants stabilize beta-catenin pathway

REACT_228137

S45 mutants of beta-catenin aren't phosphorylated pathway

REACT_228048

deletions in the AMER1 gene destabilize the destruction complex pathway

REACT_115566

Cell Cycle pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_160301

Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway

REACT_228159

S33 mutants of beta-catenin aren't phosphorylated pathway

REACT_228060

truncations of AMER1 destabilize the destruction complex pathway

REACT_228229

phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway

REACT_22232

Signaling by Interleukins pathway

REACT_160248

Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway

REACT_299

Signaling by NOTCH pathway

REACT_2203

G2/M Transition pathway

REACT_228112

deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway

REACT_118859

Signaling by NOTCH1 pathway

REACT_152

Cell Cycle, Mitotic pathway

REACT_160133

Signaling by NOTCH1 HD Domain Mutants in Cancer pathway

REACT_228223

TCF7L2 mutants don't bind CTBP pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

REACT_21391

Mitotic G2-G2/M phases pathway

REACT_118773

Signaling by the B Cell Receptor (BCR) pathway

REACT_118638

Downstream signaling events of B Cell Receptor (BCR) pathway

REACT_228251

S37 mutants of beta-catenin aren't phosphorylated pathway

REACT_116125

Disease pathway

KEGG

hsa04310

Wnt signaling pathway pathway

hsa04350

TGF-beta signaling pathway pathway

hsa04110

Cell cycle pathway

hsa04120

Ubiquitin mediated proteolysis pathway

hsa04710

Circadian rhythm pathway

hsa04114

Oocyte meiosis pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

INOH website

IL-1 signaling pathway pathway

INOH website

Toll-like receptor signaling pathway pathway

INOH website

Wnt signaling pathway pathway

INOH website

Hedgehog signaling pathway pathway

PID NCI

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

betacatenin_deg_pathway

Degradation of beta catenin

notch_pathway

Notch signaling pathway

Cross-References

SwissProt

TrEMBL

B3KU45 Q75MQ1

UniProt Splice Variant

Entrez Gene

8454

UniGene

RefSeq

NM_003592 XM_005250060

HUGO

HGNC:2551

OMIM

603134

CCDS

CCDS34772

HPRD

IMGT

EMBL

AC006323 AK096505

GenPept

AAS02034 BAG53307

RNA Seq Atlas

8454