InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CUL1

Summary

InnateDB Protein

IDBP-807321.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUL1

Protein Name

cullin 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000473318

InnateDB Gene

IDBG-46918 (CUL1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 775 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	775 [view]
Protein-Protein	774 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007050	cell cycle arrest
GO:0007219	Notch signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0097193	intrinsic apoptotic signaling pathway