InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EZH2

Summary

InnateDB Gene

IDBG-47019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EZH2

Gene Name

enhancer of zeste homolog 2 (Drosophila)

Synonyms

ENX-1; ENX1; EZH1; EZH2b; KMT6; KMT6A; WVS; WVS2

Species

Homo sapiens

Ensembl Gene

ENSG00000106462

Encoded Proteins

IDBP-47021

enhancer of zeste homolog 2 (Drosophila)

IDBP-47023

enhancer of zeste homolog 2 (Drosophila)

IDBP-475409

enhancer of zeste homolog 2 (Drosophila)

IDBP-475906

enhancer of zeste homolog 2 (Drosophila)

IDBP-484938

enhancer of zeste homolog 2 (Drosophila)

IDBP-478394

enhancer of zeste homolog 2 (Drosophila)

IDBP-484535

enhancer of zeste homolog 2 (Drosophila)

IDBP-476100

enhancer of zeste homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26668377

[Mus musculus] Selective loss of the histone-lysine N-methyltransferase Ezh2 or inhibition of its enzymatic activity increases generation of the Il2rb (CD122) natural killer (NK) precursors and mature NK progeny.

Entrez Gene

Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:148807383-148884321

Strand

Reverse strand

Band

q36.1

Transcripts

ENST00000320356	ENSP00000320147
ENST00000350995	ENSP00000223193
ENST00000492143	ENSP00000417377
ENST00000478654	ENSP00000417062
ENST00000460911	ENSP00000419711
ENST00000476773	ENSP00000419050
ENST00000483967	ENSP00000419856
ENST00000469631
ENST00000498186
ENST00000483012	ENSP00000417704

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 328 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	328 [view]
Protein-Protein	308 [view]
Protein-DNA	20 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0031490	chromatin DNA binding
GO:0042054	histone methyltransferase activity
GO:0043565	sequence-specific DNA binding
GO:0046976	histone methyltransferase activity (H3-K27 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001932	regulation of protein phosphorylation
GO:0006306	DNA methylation
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010468	regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0014013	regulation of gliogenesis
GO:0016571	histone methylation
GO:0021695	cerebellar cortex development
GO:0032320	positive regulation of Ras GTPase activity
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
GO:0034968	histone lysine methylation
GO:0042127	regulation of cell proliferation
GO:0043406	positive regulation of MAP kinase activity
GO:0045605	negative regulation of epidermal cell differentiation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0050767	regulation of neurogenesis
GO:0051154	negative regulation of striated muscle cell differentiation
GO:0070301	cellular response to hydrogen peroxide
GO:0070314	G1 to G0 transition
GO:0070734	histone H3-K27 methylation
GO:0071168	protein localization to chromatin
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0035098	ESC/E(Z) complex
GO:0045120	pronucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029687

View Gene Order

ENSBTAG00000009426

Not yet available

Pathways

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_200808

PRC2 methylates histones and DNA pathway

REACT_200857

Epigenetic regulation of gene expression pathway

REACT_169274

Cellular Senescence pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.444082

RefSeq

NM_001203247 NM_001203248 NM_001203249 NM_004456 NM_152998 XM_005249962 XM_005249963 XM_005249964 XM_006715883 XM_006715885

HUGO

OMIM

CCDS

CCDS56516 CCDS56517 CCDS56518 CCDS5891 CCDS5892

HPRD

03342

IMGT

EMBL

GenPept

RNA Seq Atlas