Version 5.4
| Homo sapiens Gene: GRPR | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-47111.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | GRPR | ||||||||||||||||||
| Gene Name | gastrin-releasing peptide receptor | ||||||||||||||||||
| Synonyms | BB2 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000126010 | ||||||||||||||||||
| Encoded Proteins |
gastrin-releasing peptide receptor
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome X:16123556-16153021 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p22.2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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| KEGG |
Neuroactive ligand-receptor interaction pathway
Calcium signaling pathway pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P30550 | ||||||||||||||||||
| TrEMBL | X5D7H2 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 2925 | ||||||||||||||||||
| UniGene | Hs.567282 | ||||||||||||||||||
| RefSeq | NM_005314 | ||||||||||||||||||
| HUGO | HGNC:4609 | ||||||||||||||||||
| OMIM | 305670 | ||||||||||||||||||
| CCDS | CCDS14174 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF293321 AF293322 AF293323 AK313588 BC074733 CH471074 KJ534854 KJ534855 M73481 | ||||||||||||||||||
| GenPept | AAA88050 AAH74733 AAL96377 AHW56494 AHW56495 BAG36357 EAW98909 | ||||||||||||||||||
| RNA Seq Atlas | 2925 | ||||||||||||||||||