InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRPR

Summary

InnateDB Protein

IDBP-47113.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRPR

Protein Name

gastrin-releasing peptide receptor

Synonyms

BB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000369643

InnateDB Gene

IDBG-47111 (GRPR)

Protein Structure

UniProt Annotation

Function

Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain. {ECO:0000269PubMed:11245983}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004946	bombesin receptor activity
GO:0005515	protein binding
GO:0008528	G-protein coupled peptide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0008283	cell proliferation
GO:0031989	bombesin receptor signaling pathway
GO:0042127	regulation of cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR001556 Bombesin receptor
IPR001966 Gastrin-releasing peptide receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)

PFAM

PF00001
PF10320
PF10323

PRINTS

PR00237
PR01012
PR00358
PR00640

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30550