Version 5.4
Homo sapiens Gene: SOS1
Summary
InnateDB Gene IDBG-47279.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOS1
Gene Name son of sevenless homolog 1 (Drosophila)
Synonyms GF1; GGF1; GINGF; HGF; NS4
Species Homo sapiens
Ensembl Gene ENSG00000115904
Encoded Proteins
IDBP-240361
son of sevenless homolog 1 (Drosophila)
IDBP-293918
son of sevenless homolog 1 (Drosophila)
IDBP-373300
son of sevenless homolog 1 (Drosophila)
IDBP-373306
son of sevenless homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:38981396-39124345
Strand Reverse strand
Band p22.1
Transcripts
ENST00000395038 ENSP00000378479
ENST00000402219 ENSP00000384675
ENST00000426016 ENSP00000387784
ENST00000451331 ENSP00000393899
ENST00000469581
ENST00000474390
ENST00000472480
ENST00000461545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 71 [view]
Protein-Protein 71 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0030168 platelet activation
GO:0032318 regulation of Ras GTPase activity
GO:0032320 positive regulation of Ras GTPase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024241
View Gene Order
ENSBTAG00000011643
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_56
Prolactin pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_15443
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_12033
Signalling to RAS pathway
REACT_13638
NRAGE signals death through JNK pathway
REACT_524
SOS-mediated signalling pathway
REACT_508
Signal attenuation pathway
REACT_12579
SHC1 events in EGFR signaling pathway
REACT_12606
GRB2 events in EGFR signaling pathway
REACT_9417
Signaling by EGFR pathway
REACT_121096
EGFR Transactivation by Gastrin pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_11051
Rho GTPase cycle pathway
REACT_661
SHC-mediated signalling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150139
SHC-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21374
SHC-mediated cascade pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_115852
Signaling by constitutively active EGFR pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_19226
Activation of Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_999
SHC-related events pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_22232
Signaling by Interleukins pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04912
GnRH signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04540
Gap junction pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa05213
Endometrial cancer pathway
hsa05214
Glioma pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04320
Dorso-ventral axis formation pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
HGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
IGF1 signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
rac1_reg_pathway
Regulation of RAC1 activity
il2_1pathway
IL2-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
erbb1_internalization_pathway
Internalization of ErbB1
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
erbb1_downstream_pathway
ErbB1 downstream signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
igf1_pathway
IGF1 pathway
epopathway
EPO signaling pathway
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
fgf_pathway
FGF signaling pathway
bcr_5pathway
BCR signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
et_egfrpathway
EGFR-dependent Endothelin signaling events
tcptp_pathway
Signaling events mediated by TCPTP
ras_pathway
Regulation of Ras family activation
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
ret_pathway
Signaling events regulated by Ret tyrosine kinase
tgfbrpathway
TGF-beta receptor signaling
shp2_pathway
SHP2 signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
gmcsf_pathway
GMCSF-mediated signaling events
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
pdgfrapathway
PDGFR-alpha signaling pathway
il2_pi3kpathway
IL2 signaling events mediated by PI3K
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.604256 Hs.709893
RefSeq NM_005633
HUGO
OMIM
CCDS CCDS1802
HPRD 01681
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca