InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOS1

Summary

InnateDB Protein

IDBP-240361.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOS1

Protein Name

son of sevenless homolog 1 (Drosophila)

Synonyms

GF1; GGF1; GINGF; HGF; NS4;

Species

Homo sapiens

Ensembl Protein

ENSP00000378479

InnateDB Gene

IDBG-47279 (SOS1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	71 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001849 Pleckstrin homology domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR007125 Histone core
IPR009072 Histone-fold
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00621
PF00618
PF00169
PF00617
PF00125

PRINTS

PIRSF

SMART

SM00325
SM00229
SM00233
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite