Version 5.4
Homo sapiens Gene: TOMM70A
Summary
InnateDB Gene IDBG-47323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOMM70A
Gene Name translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154174
Encoded Proteins
IDBP-47325
translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20628368
TOMM70A, a mitochondrial import receptor, interacts with MAVS upon RNA virus infection acting as a critical adaptor bridging TBK1/IRF3 to MAVS.
Entrez Gene
Summary This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:100363431-100401398
Strand Reverse strand
Band q12.2
Transcripts
ENST00000284320 ENSP00000284320
ENST00000483945
ENST00000492171
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 35 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0071806 protein transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005742 mitochondrial outer membrane translocase complex
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022752
View Gene Order
ENSBTAG00000014302
Not yet available
Pathways
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.227253 Hs.706175
RefSeq NM_014820
HUGO
OMIM
CCDS CCDS33807
HPRD 16194
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca