Homo sapiens Gene: RLN2
Summary
InnateDB Gene IDBG-47326.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RLN2
Gene Name relaxin 2
Synonyms bA12D24.1.1; bA12D24.1.2; H2; H2-RLX; RLXH2
Species Homo sapiens
Ensembl Gene ENSG00000107014
Encoded Proteins
relaxin 2
relaxin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:5299868-5304969
Strand Reverse strand
Band p24.1
Transcripts
ENST00000381627 ENSP00000371040
ENST00000416837 ENSP00000399616
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0007565 female pregnancy
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Relaxin receptors pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.127032
RefSeq NM_005059 NM_134441
HUGO
OMIM
CCDS CCDS6460
HPRD 01561
IMGT
EMBL
GenPept
RNA Seq Atlas