Version 5.4
Homo sapiens Protein: RLN2
Summary
InnateDB Protein IDBP-47328.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RLN2
Protein Name relaxin 2
Synonyms bA12D24.1.1; bA12D24.1.2; H2; H2-RLX; RLXH2;
Species Homo sapiens
Ensembl Protein ENSP00000371040
InnateDB Gene IDBG-47326 (RLN2)
Protein Structure
UniProt Annotation
Function Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary. {ECO:0000269PubMed:6548702, ECO:0000269PubMed:8735594}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0007565 female pregnancy
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR016179 Insulin-like
IPR022352 Insulin family
IPR022421 Relaxin
PFAM PF00049
PRINTS PR00276
PR02004
PIRSF
SMART SM00078
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04090
PhosphoSite PhosphoSite-P04090
TrEMBL
UniProt Splice Variant
Entrez Gene 6019
UniGene Hs.127032
RefSeq NP_604390
HUGO HGNC:10027
OMIM 179740
CCDS CCDS6460
HPRD 01561
IMGT
EMBL AF104935 AL135786 BC126415 BC126419 S83200 X00948
GenPept AAD14429 AAD21961 AAI26416 AAI26420 CAA25460 CAC04177

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca