Version 5.4
Homo sapiens Gene: SIL1
Summary
InnateDB Gene IDBG-47481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIL1
Gene Name SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120725
Encoded Proteins
IDBP-47483
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
IDBP-240805
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
IDBP-481545
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
IDBP-475193
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
IDBP-483842
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
IDBP-478090
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
IDBP-478661
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
IDBP-475413
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
IDBP-478504
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:138946720-139293557
Strand Reverse strand
Band q31.2
Transcripts
ENST00000265195 ENSP00000265195
ENST00000394817 ENSP00000378294
ENST00000440765
ENST00000515008
ENST00000509534 ENSP00000426858
ENST00000503732
ENST00000505945 ENSP00000425136
ENST00000508639 ENSP00000427371
ENST00000513453 ENSP00000424014
ENST00000507002 ENSP00000421890
ENST00000505830 ENSP00000426460
ENST00000505353 ENSP00000423662
ENST00000504666
ENST00000509400
ENST00000508744
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006886 intracellular protein transport
Cellular Component
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024357
View Gene Order
ENSBTAG00000033747
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6R940 D6RAI3 D6RG16
UniProt Splice Variant
Entrez Gene 64374
UniGene Hs.483521 Hs.743921
RefSeq NM_001037633 NM_022464 XM_006714671
HUGO HGNC:24624
OMIM 608005
CCDS CCDS4209
HPRD 12150
IMGT
EMBL AC008614 AC011378 AC011404 AC011405
GenPept
RNA Seq Atlas 64374

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca