Version 5.4
Homo sapiens Gene: LPXN
Summary
InnateDB Gene IDBG-47733.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPXN
Gene Name leupaxin
Synonyms LDPL
Species Homo sapiens
Ensembl Gene ENSG00000110031
Encoded Proteins
IDBP-240295
leupaxin
IDBP-600465
leupaxin
IDBP-587425
leupaxin
IDBP-719252
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:58526871-58578220
Strand Reverse strand
Band q12.1
Transcripts
ENST00000395074 ENSP00000378512
ENST00000530561 ENSP00000437094
ENST00000528954 ENSP00000431284
ENST00000528489 ENSP00000461855
ENST00000529915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006461 protein complex assembly
GO:0007155 cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0050859 negative regulation of B cell receptor signaling pathway
Cellular Component
GO:0002102 podosome
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0042995 cell projection
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024696
View Gene Order
ENSBTAG00000036260
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001143995 NM_004811 XM_006718750
HUGO
OMIM
CCDS CCDS53635 CCDS7969
HPRD 05651
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca