InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPXN

Summary

InnateDB Protein

IDBP-587425.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPXN

Protein Name

leupaxin

Synonyms

LDPL;

Species

Homo sapiens

Ensembl Protein

ENSP00000431284

InnateDB Gene

IDBG-47733 (LPXN)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269PubMed:17640867, ECO:0000269PubMed:18451096, ECO:0000269PubMed:18497331, ECO:0000269PubMed:20543562}.

Subcellular Localization

Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B- cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.

Disease Associations

Tissue Specificity

Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression. {ECO:0000269PubMed:12674328, ECO:0000269PubMed:18451096, ECO:0000269PubMed:18497331}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0050859	negative regulation of B cell receptor signaling pathway

Cellular Component

GO:0002102	podosome
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0042995	cell projection
GO:0048471	perinuclear region of cytoplasm