Homo sapiens Gene: ZFP91
Summary
InnateDB Gene IDBG-47776.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol ZFP91
Gene Name zinc finger protein 91 homolog (mouse)
Synonyms DMS-8; DSM-8; PZF; ZFP-91; ZNF757;
Species Homo sapiens
Ensembl Gene ENSG00000186660
Encoded Proteins
zinc finger protein 91 homolog (mouse)
Protein Structure
Entrez Gene
Summary The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:58346584-58388515
Strand Forward strand
Band q12.1
Transcripts
ENST00000316059 ENSP00000339030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004842 ubiquitin-protein ligase activity
GO:0008270 zinc ion binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0070534 protein K63-linked ubiquitination
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q96JP5
TrEMBL B4DIN6
UniProt Splice Variant
Entrez Gene 80829
UniGene Hs.524920 Hs.621869 Hs.732346
RefSeq NM_001197051 NM_053023
HUGO 14983
OMIM
CCDS CCDS31553
HPRD 11700
IMGT
EMBL AB056107 AB057443 AF310246 AK295700 AP001350 BC051743 CH471076
GenPept AAH51743 AAL09963 BAB63373 BAB63374 BAG58548 EAW73811
ImmGen ZFP91 (murine)
RNA Seq Atlas 80829