InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP6V0E2

Summary

InnateDB Gene

IDBG-47786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0E2

Gene Name

ATPase, H+ transporting V0 subunit e2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000171130

Encoded Proteins

IDBP-387271

ATPase, H+ transporting V0 subunit e2

IDBP-387272

ATPase, H+ transporting V0 subunit e2

IDBP-387273

ATPase, H+ transporting V0 subunit e2

IDBP-480501

ATPase, H+ transporting V0 subunit e2

IDBP-473536

ATPase, H+ transporting V0 subunit e2

IDBP-475615

ATPase, H+ transporting V0 subunit e2

IDBP-812204

ATPase, H+ transporting V0 subunit e2

IDBP-812203

ATPase, H+ transporting V0 subunit e2

IDBP-812214

ATPase, H+ transporting V0 subunit e2

IDBP-812216

ATPase, H+ transporting V0 subunit e2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:149872968-149880698

Strand

Forward strand

Band

q36.1

Transcripts

ENST00000456496	ENSP00000410220
ENST00000425642	ENSP00000396148
ENST00000421974	ENSP00000411672
ENST00000479613	ENSP00000417939
ENST00000464683	ENSP00000420012
ENST00000471877	ENSP00000420679
ENST00000464662	ENSP00000475645
ENST00000483478
ENST00000495408
ENST00000490092
ENST00000606024	ENSP00000475904
ENST00000615196	ENSP00000481176
ENST00000611515	ENSP00000482231

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0042625	ATPase activity, coupled to transmembrane movement of ions

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0007035	vacuolar acidification
GO:0008152	metabolic process
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0016049	cell growth
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain