InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V0E2

Summary

InnateDB Protein

IDBP-475615.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0E2

Protein Name

ATPase, H+ transporting V0 subunit e2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000420679

InnateDB Gene

IDBG-47786 (ATP6V0E2)

Protein Structure

UniProt Annotation

Function

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed at high levels in heart, brain and kidney and also detected in inner ear epithelium, vestibule, testis, epididymis and bladder. Isoform 2 is expressed in heart, kidney, placenta and pancreas. Isoform 2 is not detected in frontal cortex, but is prevalent in all other brain areas. {ECO:0000269PubMed:17350184}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0042625	ATPase activity, coupled to transmembrane movement of ions

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0007035	vacuolar acidification
GO:0008152	metabolic process
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0016049	cell growth
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain