Version 5.4
Homo sapiens Gene: SPINT2
Summary
InnateDB Gene IDBG-48406.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPINT2
Gene Name serine peptidase inhibitor, Kunitz type, 2
Synonyms DIAR3; HAI-2; HAI2; Kop; PB
Species Homo sapiens
Ensembl Gene ENSG00000167642
Encoded Proteins
IDBP-48408
serine peptidase inhibitor, Kunitz type, 2
IDBP-379132
serine peptidase inhibitor, Kunitz type, 2
IDBP-766194
IDBP-763760
IDBP-761806
IDBP-765505
IDBP-765026
IDBP-765322
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38244035-38292614
Strand Forward strand
Band q13.2
Transcripts
ENST00000301244 ENSP00000301244
ENST00000454580 ENSP00000389788
ENST00000589749
ENST00000590738 ENSP00000468728
ENST00000587090 ENSP00000466407
ENST00000587334 ENSP00000468519
ENST00000590210
ENST00000590510 ENSP00000465301
ENST00000592007 ENSP00000465561
ENST00000587516 ENSP00000465721
ENST00000585357
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0006928 cellular component movement
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074227
View Gene Order
ENSBTAG00000000182
Not yet available
Cross-References
SwissProt
TrEMBL K7EKQ0
UniProt Splice Variant
Entrez Gene 10653
UniGene Hs.31439
RefSeq NM_001166103 NM_021102
HUGO HGNC:11247
OMIM 605124
CCDS CCDS12510 CCDS54261
HPRD 05495
IMGT
EMBL AC011479
GenPept
RNA Seq Atlas 10653

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca