Version 5.4
Homo sapiens Protein: SPINT2
Summary
InnateDB Protein IDBP-379132.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPINT2
Protein Name serine peptidase inhibitor, Kunitz type, 2
Synonyms DIAR3; HAI-2; HAI2; Kop; PB;
Species Homo sapiens
Ensembl Protein ENSP00000389788
InnateDB Gene IDBG-48406 (SPINT2)
Protein Structure
UniProt Annotation
Function Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations Diarrhea 3, secretory sodium, congenital (DIAR3) [MIM:270420]: A disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes. {ECO:0000269PubMed:19185281}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0006928 cellular component movement
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002223 Proteinase inhibitor I2, Kunitz metazoa
PFAM PF00014
PRINTS PR00759
PIRSF
SMART SM00131
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43291
PhosphoSite PhosphoSite-O43291
TrEMBL
UniProt Splice Variant
Entrez Gene 10653
UniGene Hs.31439
RefSeq NP_001159575
HUGO HGNC:11247
OMIM 605124
CCDS CCDS54261
HPRD 05495
IMGT
EMBL AB006534 AC011479 AF027205 AK291532 AK297154 BC001668 BC007705 BC011951 BC011955 BC012868 BT020115 BT020116 BT020117 CH471126 U78095
GenPept AAB84031 AAC02781 AAH01668 AAH07705 AAH11951 AAH11955 AAH12868 AAV38918 AAV38919 AAV38920 BAA25024 BAF84221 BAG59653 EAW56766 EAW56767

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca