InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STX3

Summary

InnateDB Gene

IDBG-48547.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX3

Gene Name

syntaxin 3

Synonyms

STX3A

Species

Homo sapiens

Ensembl Gene

ENSG00000166900

Encoded Proteins

IDBP-48549

syntaxin 3

IDBP-48551

syntaxin 3

IDBP-592991

syntaxin 3

IDBP-603939

syntaxin 3

IDBP-583966

syntaxin 3

IDBP-589339

syntaxin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:59713456-59802706

Strand

Forward strand

Band

q12.1

Transcripts

ENST00000337979	ENSP00000338562
ENST00000300150	ENSP00000300150
ENST00000533637	ENSP00000436200
ENST00000529177	ENSP00000433248
ENST00000530498
ENST00000528805	ENSP00000431386
ENST00000530221	ENSP00000434836

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0005515	protein binding
GO:0050544	arachidonic acid binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0016192	vesicle-mediated transport
GO:0031175	neuron projection development
GO:0060291	long-term synaptic potentiation
GO:0061025	membrane fusion

Cellular Component

GO:0005773	vacuole
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030141	secretory granule
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031201	SNARE complex
GO:0042581	specific granule
GO:0042582	azurophil granule
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041488

View Gene Order

ENSBTAG00000012820

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04130

SNARE interactions in vesicular transport pathway

INOH

PID NCI

Cross-References

SwissProt

Q13277

TrEMBL

E9PN33 E9PQJ8 F8W9Y0 Q53YE2

UniProt Splice Variant

Entrez Gene

6809

UniGene

Hs.593364 Hs.593594

RefSeq

NM_001178040 NM_004177 XM_005274195 XM_005274196 XM_005274199

HUGO

HGNC:11438

OMIM

600876

CCDS

CCDS53637 CCDS7975

HPRD

IMGT

EMBL

AJ002076 AJ002077 AK125660 AK290251 AK297419 AK312909 AP000640 BC007405 BC007429 BT006666 CH471076 U32315 X90581

GenPept

AAA75303 AAH07405 AAH07429 AAP35312 BAF82940 BAG35755 BAG54232 BAG59852 CAA05175 CAA05176 CAA62209 EAW73854 EAW73855

RNA Seq Atlas

6809