InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcne1l

Summary

InnateDB Gene

IDBG-486772.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcne1l

Gene Name

potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene

Synonyms

1500015C14Rik; Kcne5; Mink

Species

Mus musculus

Ensembl Gene

ENSMUSG00000090122

Encoded Proteins

IDBP-624699

potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176076:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. This intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:142304752-142306294

Strand

Reverse strand

Band

Transcripts

ENSMUST00000134825

ENSMUSP00000127773

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005249	voltage-gated potassium channel activity
GO:0015459	potassium channel regulator activity
GO:0044325	ion channel binding
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

Biological Process

GO:0006811	ion transport
GO:0008016	regulation of heart contraction
GO:0060048	cardiac muscle contraction
GO:0060306	regulation of membrane repolarization
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization
GO:0071435	potassium ion export
GO:0071805	potassium ion transmembrane transport
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086014	atrial cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:1901379	regulation of potassium ion transmembrane transport
GO:1901380	negative regulation of potassium ion transmembrane transport
GO:1901381	positive regulation of potassium ion transmembrane transport
GO:2001257	regulation of cation channel activity

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000176076

View Gene Order

ENSBTAG00000012319

Not yet available

Cross-References

SwissProt

Q9QZ26

TrEMBL

UniProt Splice Variant

Entrez Gene

66240

UniGene

Mm.58507

RefSeq

NM_021487

OMIM

CCDS

CCDS30447

HPRD

IMGT

MGI ID

MGI:1913490

MGI Symbol

Kcne1l

EMBL

AJ131398 BC028942

GenPept

AAH28942 CAB58362

RNA Seq Atlas

66240