Version 5.4
Homo sapiens Gene: ZFP36L2
Summary
InnateDB Gene IDBG-48686.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFP36L2
Gene Name zinc finger protein 36, C3H type-like 2
Synonyms BRF2; ERF-2; ERF2; RNF162C; TIS11D
Species Homo sapiens
Ensembl Gene ENSG00000152518
Encoded Proteins
IDBP-48690
zinc finger protein 36, C3H type-like 2
IDBP-808127
ZFP36 ring finger protein-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:43222402-43226609
Strand Reverse strand
Band p21
Transcripts
ENST00000282388 ENSP00000282388
ENST00000620081 ENSP00000478940
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0017091 AU-rich element binding
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006355 regulation of transcription, DNA-templated
GO:0006402 mRNA catabolic process
GO:0008283 cell proliferation
GO:0030097 hemopoiesis
GO:0033077 T cell differentiation in thymus
GO:0035019 somatic stem cell maintenance
GO:0043488 regulation of mRNA stability
GO:0048103 somatic stem cell division
GO:0060216 definitive hemopoiesis
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000737 negative regulation of stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045817
View Gene Order
ENSBTAG00000003553
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.503093
RefSeq NM_006887
HUGO
OMIM
CCDS CCDS1811
HPRD 18319
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca